The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 128, 1255-1265, Copyright © 1968 by The Rockefeller University Press

ARTICLE

CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY : II. CORRELATION OF THE IN VITRO RESPONSE WITH SKIN REACTIVITY.



Nancy H. Ruddle Ph.D.1 and Byron H. Waksman M.D.1

1 From the Department of Microbiology, Yale University School of Medicine, New Haven, Connecticut 06510

Damage of rat embryo fibroblasts in the presence of sensitized lymph node cells reacting with specific antigen was shown to be closely correlated with delayed hypersensitivity in the animals from which the lymph node cells were taken. The phenomenon was not correlated with Arthus reactivity. In. animals sensitized with picryl conjugates of ovalbumin or human serum albumin, skin reactivity and the in vitro cytotoxic effect could be elicited only with the homologous conjugate or the protein carrier alone and not with picryl conjugates of heterologous proteins. Lewis rats developed more intense delayed sensitivity than BN rats, and Lewis lymph node cells were correspondingly more effective in producing specific damage of both syngeneic and allogeneic fibroblasts.

Submitted on May 31, 1968


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