A SUBCLASS OF HUMAN gammaA-GLOBULINS (gammaA2) WHICH LACKS THE DISULFIDE BONDS LINKING HEAVY AND LIGHT CHAINS

doi:10.1084/jem.128.6.1223

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A SUBCLASS OF HUMAN $gamma$ A-GLOBULINS ( $gamma$ A2) WHICH LACKS THE DISULFIDE BONDS LINKING HEAVY AND LIGHT CHAINS

Howard M. Grey M.D.¹, Carlos A. Abel M.D.¹, William J. Yount M.D.¹, and Henry G. Kunkel M.D.¹

¹ From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037, and The Rockefeller University, New York 10021

The $gamma$ A2-subgroup of $gamma$ A-globulins, previously delineated by antigenicstudies, was found to differ strikingly from other immunoglobulinsin the manner in which the polypeptide chains are bound together.The heavy and light chains were not linked to each other bydisulfide bonds. Instead the light chains were disulfide linkedto one another, and were present in the $gamma$ A2-molecule as disulfidebridged L-L dimers.

Antisera specific for $gamma$ A2-proteins indicatedthe occurrence of two different antigenic types in all normalsera as well as saliva and colostrum. Both of these showed theunique interchain disulfide linkage. Quantitative analyses indicatedhigher levels of $gamma$ A2-proteins in external secretions.

Submitted on July 12, 1968

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