The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 128, 47-68, Copyright © 1968 by The Rockefeller University Press

ARTICLE

ABNORMALITIES OF IN VITRO LYMPHOCYTE RESPONSES DURING RUBELLA VIRUS INFECTIONS

George B. Olson Ph.D.1, Peter B. Dent M.D.1, William E. Rawls M.D.1, Mary Ann South M.D.1, J. R. Montgomery M.D.1, Joseph L. Melnick Ph.D.1, and Robert A. Good M.D.1

1 From the Pediatric Research Laboratories of the Variety Club Heart Hospital, University of Minnesota, Minneapolis, Minnesota 55455, and the Departments of Pediatrics and of Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas 77025

In vitro rubella virus infections of lymphocytes from normal adult humans impaired their responsiveness to phytohemagglutinin (PHA) stimulations; a situation which seemed analogous to the PHA unresponsiveness of peripheral lymphocytes from babies with the congenital rubella syndrome. Such in vitro viral infection of normal cells also decreased the synthesis of normal nucleic acids and structural proteins, and abrogated the enhanced DNA synthesis induced by pokeweed and specific antigen stimulations. Furthermore, it was shown that live rubella virus, but not ultraviolet-irradiated virus, was necessary for the impaired mitogenic responses of normal leukocytes.

These observations are interpreted to favor the view that the virus achieves its inhibitory effect on the action of mitogens by interference either directly or indirectly at an intracellular site. Such an action could reduce the functional potential of lymphocytes and impair their effectiveness as immunologically competent cells or as effectors in immunologic reactions.

 Submitted on February 6, 1968


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