AUTOLOGOUS IMMUNE COMPLEX NEPHRITIS INDUCED WITH RENAL TUBULAR ANTIGEN: I. IDENTIFICATION AND ISOLATION OF THE PATHOGENETIC ANTIGEN

doi:10.1084/jem.127.3.555

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AUTOLOGOUS IMMUNE COMPLEX NEPHRITIS INDUCED WITH RENAL TUBULAR ANTIGEN : I. IDENTIFICATION AND ISOLATION OF THE PATHOGENETIC ANTIGEN

Thomas S. Edgington M.D.¹, Richard J. Glassock M.D.¹, and Frank J. Dixon M.D.¹

¹ From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

The nephritogenic antigen, responsible for the immunogenicstimulus in experimental allergic glomerulonephritis inducedwith tubular antigen, has been identified as a renal tubularepithelial (RTE)-specific antigen and has been isolated in arelatively purified form. This antigen, RTE- $alpha$ ₅, is a distinctand antigenically specific lipoprotein of high density whichis derived primarily from the brush border of proximal convolutedtubular epthelium of the rat kidney. It has been suggested thatthis molecule may be a plasma membrane subunit. Immunizationof rats with as little as 3 µg N of RTE- $alpha$ ₅ in complete Freund'sadjuvant has effectively induced this form of membranous glomerulonephritis.RTE- $alpha$ ₅ is not a constituent of normal rat glomeruli; however,with the onset of autologous immune complex nephritis it isdeposited in a granular fashion along glomerular capillary wallsindistinguishable from the deposits of $gamma$ -globulin and complement.The antigenic specificity of this antigen and its tissue derivationhas been explored, and the observations support the autologousimmune complex pathogenesis of the glomerulonephritis inducedin rats by immunization with renal tubular antigen.

Submitted on October 19, 1967

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