The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 127, 489-505, Copyright © 1968 by The Rockefeller University Press

ARTICLE

STUDIES ON STREPTOCOCCAL BACTERIOPHAGES : II. ADSORPTION STUDIES ON GROUP A AND GROUP C STREPTOCOCCAL BACTERIOPHAGES



Vincent A. Fischetti 1 and John B. Zabriskie M.D.1

1 From The Rockefeller University, New York 10021

Evidence has been presented that Group C bacteriophages differ as to their inactivating site on the streptococcal cell wall. While all three phages adsorb to isolated cell walls, only the C1 phage was inactivated by enzymatically prepared group-specific carbohydrate. None of the Group C phages were inactivated by chemically extracted group-specific carbohydrate. In contrast, all virulent Group A streptococcal bacteriophages adsorbed only to living Group A streptococci. However, Group A temperate phages were able to adsorb to isolated cell walls but not to group-specific carbohydrate.

While it has not been possible to identify the specific inactivating substance for the Group A virulent phages, certain pieces of evidence indirectly implicate the group-specific carbohydrate, specifically the N-acetylglucosamine moiety. The fact that Group A virulent phages failed to adsorb to heat-killed Group A streptococcal cells suggests that additional factors produced by the living cell are needed for complete viral inactivation.

 Submitted on November 9, 1967


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