The Journal of Experimental Medicine
Cytokines Montreal 2008
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The Journal of Experimental Medicine, Vol 126, 1127-1142, Copyright © 1967 by The Rockefeller University Press

ARTICLE

EVALUATION OF A STROMA-FREE HEMOGLOBIN SOLUTION FOR USE AS A PLASMA EXPANDER

S. Frederick Rabiner M.D.1, J. Raymond Helbert Ph.D.1, Harry Lopas M.D.1, and Lila H. Friedman 1

1 From the Division of Clinical Hematology, Department of Medicine, Michael Reese Hospital and Medical Center, and the Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60616

The preparation of large quantities of a stable, stroma-free hemoglobin solution without coagulant activity is described. Following infusion of this solution into phlebotomized dogs, there is no methemoglobin formation, no adverse effects on vital signs, and no demonstrable activation of blood coagulation. The hemoglobin maintains its oxygen-carrying capacity and liberates oxygen into tissues. Acute and chronic effects on renal function following infusion of this preparation were also studied and no effect on clearance of urea, creatinine, or P.A.H. could be demonstrated. There was no change in urinary output and histological sections revealed no lesions attributable to hemoglobin toxicity. It is concluded that a stroma-free hemoglobin solution may have use as a plasma expander.

Submitted on July 17, 1967


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