The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 126, 1005-1012, Copyright © 1967 by The Rockefeller University Press

ARTICLE

CARTILAGE MATRIX DEPLETION BY RHEUMATOID SYNOVIAL CELLS IN TISSUE CULTURE

David Hamerman M.D.1, Rosamond Janis M.D.1, and Carol Smith M.D.1

1 From the Departments of Medicine and Pathology, the Albert Einstein College of Medicine and Bronx Municipal Hospital Center, Bronx, New York 10461

Articular cartilage fragments were added to monolayer cultures of synovial membrane cells. After 3 wk of incubation, the cartilage fragments were examined histologically for metachromasia and basophilia, and for fluorescent staining using a rabbit antiserum to cartilage protein-polysaccharide. Cartilage incubated with cells derived from rheumatoid synovial membranes showed striking loss of metachromasia and basophilia as well as diminished to absent fluorescent staining. Cartilage fragments incubated with cells from normal synovia, or with cells from the synovial membrane of a patient with Reiter's syndrome, did not show these changes and resembled control cartilage incubated in tissue culture medium alone. It appears, therefore, that rheumatoid synovial cells in tissue culture are able to deplete the matrix of articular cartilage.

Submitted on July 6, 1967


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