The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 126, 763-770, Copyright © 1967 by The Rockefeller University Press

ARTICLE

QUANTITATIVE ASPECTS OF THE RELEASE OF LEUKOCYTE PYROGEN FROM RABBIT BLOOD INCUBATED WITH ENDOTOXIN

P. A. Murphy D. Phil., M.R.C.P.1

1 From the Medical Research Council Body Temperature Research Unit, Department of the Regius Professor of Medicine, The Radcliffe Infirmary, Oxford, England

This paper describes the relations between the endotoxin concentration and leukocyte pyrogen yield when endotoxin is incubated with whole rabbit blood for 24 hr. The results provide strong evidence for the view that leukocyte pyrogen is not modified endotoxin, and also show that the simplified assay method described in the previous paper works reasonably well.

Submitted on March 23, 1967


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