The Journal of Experimental Medicine
ThymUS '08
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The Journal of Experimental Medicine, Vol 125, 863-872, Copyright © 1967 by The Rockefeller University Press

ARTICLE

QUANTITATIVE STUDIES OF PHYTOHEMAGGLUTININ-INDUCED DNA AND RNA SYNTHESIS IN NORMAL AND AGAMMAGLOBULINEMIC LEUKOCYTES

Douglass C. Tormey M.D.1, Roberta Kamin 1, and H. Hugh Fudenberg M.D.1

1 From the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco

Leukocytes from nine patients with acquired agammaglobulinemia were studied in vitro. Synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) induced by phytohemagglutinin was measured by determination of the degree of incorporation of labeled precursor. Synthesis of both DNA and RNA was decreased in the agammaglobulinemic cells. The presence of an inhibitor in the patients' sera could not be demonstrated. These results suggest that the basic defect in agammaglobulinemia is cellular rather than humoral.

Submitted on January 12, 1967


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