The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 124, 1031-1038, Copyright © 1966 by The Rockefeller University Press

ARTICLE

IMMUNOPATHOLOGY OF NZB/BL MICE : V. VIRUSLIKE (FILTRABLE) AGENT SEPARABLE FROM LYMPHOMA CELLS AND IDENTIFIABLE BY ELECTRON MICROSCOPY



Robert C. Mellors M.D.1 and Chen Ya Huang Ph.D.1

1 From The Hospital for Special Surgery, Affiliated with the New York Hospital-Cornell University Medical College, and the Departments of Pathology and Anatomy, Cornell University Medical College, New York

A filtrable agent separable from transplantable malignant lymphomas of NZB/Bl mice was capable, upon inoculation into preweanling NZB/Bl mice, of inducing lymphoid cell hyperplasia, hypergammaglobulinemia, proteinuria, hypoalbuminemia, and pathological changes (focal membranous glomerulonephritis) of kidneys—renal functional and structural changes qualitatively similar to those of spontaneous occurrence in older NZB/Bl mice.

Viruslike particles with close resemblance to the typical "C" type murine oncogenic virus particles were identified by means of electron microscopy in NZB/Bl mouse tissues and cells, including malignant lymphoma cells, benign lymphoid cells of thymus and spleen, epithelial cells of renal tubules, and extracellular sites.

The relevance of these observations, the first of their kind dealing with NZB/Bl mice, is discussed in relation to the several immunopathological disorders which characterize this strain of mice.

 Submitted on July 19, 1966


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