The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 124, 819-832, Copyright © 1966 by The Rockefeller University Press

ARTICLE

OCCURRENCE AND PROPERTIES OF A MACROGLOBULIN DIMER IN SOME HYPERGLOBULINEMIC SERA

T. Suzuki M.D.1 and H. F. Deutsch Ph.D.1

1 From the Department of Physiological Chemistry, The University of Wisconsin, Madison

A 22S human gammaM-globulin component has been subjected to various study. It appears to be a dimer of 19S proteins and can undergo reversible molecular transitions which are both pH and temperature dependent. The 22S material regenerated from its 8S subunits no longer undergo similar transformations. Efforts to demonstrate that the 22S material was an antigen-antibody complex of 19S molecules were unsuccessful. Complex precipitin reactions in gels are given by macroglobulins containing this component with antibody to L chains.

Submitted on May 26, 1966


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