¹ From the Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California

A strain of rabbits with an inherited complement deficiency was shown to lack the sixth component of the hemolytic complement system. A method was elaborated for the partial purification of this component from normal rabbit serum. Upon injection of partially purified rabbit C'6 into C'6-deficient animals, an antibody was obtained which specifically inhibited the hemolytic activity of C'6. The data suggest that C'6-deficient serum either lacks the C'6 molecule or contains it in a chemically modified and inactive form.

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This article has been cited by other articles:

• Winkelstein, J., Cork, L., Griffin, D., Griffin, J., Adams, R., Price, D. (1981). Genetically determined deficiency of the third component of complement in the dog. Science 212: 1169-1170 [Abstract]  
• Colten, H. R., Parkman, R. (1972). Biosynthesis of C4 (Fourth Component of Complement) by Hybrids of C4-Deficient Guinea Pig Cells and HeLa Cells. Science 176: 1029-1031 [Abstract]  

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