HOST-PARASITE RELATIONS IN MOUSE TYPHOID

doi:10.1084/jem.124.4.573

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ARTICLE

HOST-PARASITE RELATIONS IN MOUSE TYPHOID

G. B. Mackaness M.B.¹, R. V. Blanden ¹, and F. M. Collins Ph.D.¹

¹ From the Trudeau Institute, Medical Research Laboratories, Saranac Lake, New York

The development of acquired resistance to Salmonella typhimuriumhas been studied in mice infected intravenously with small numbersof streptomycin-sensitive or streptomycin-resistant organisms.By the 14th day of a primary infection the mouse develops amechanism capable of destroying completely a super infectingdose of organisms, but is unable to eliminate organisms of theprimary infection. The latter are constantly returned to thecirculation from necrotic foci at the sites of implantation.Passive transfer of serum from actively infected or vaccinatedanimals, and immunization with heat-killed organisms, increasethe capacity of the host to clear organisms from the blood,but do not interfere to any significant extent with their subsequentmultiplication in the tissues. It is concluded that the resistanceof actively infected animals depends on a nonhumoral mechanismcapable of destroying organisms from endogenous or exogenoussources.

Submitted on May 18, 1966

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