The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 123, 767-775, Copyright © 1966 by The Rockefeller University Press

ARTICLE

THE INFLUENCE OF CORTISONE ON EXPERIMENTAL VIRAL INFECTION : VIII. SUPPRESSION BY CORTISONE OF INTERFERON FORMATION IN MICE INJECTED WITH NEWCASTLE DISEASE VIRUS



Michael W. Rytel M.D.1 and Edwin D. Kilbourne M.D.1

1 From the Division of Virus Research, Department of Public Health, Cornell University Medical College, New York

The administration, of 5.0 mg of cortisone 6 to 24 hr prior to the intravenous injection of mice with NDV was associated with a marked reduction in the interferon response as measured in serum and spleen. Reduced concentrations of interferon following cortisone pretreatment were demonstrable from 6 to 16 hr following injection of virus.

Submitted on December 27, 1965


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