RABBIT LYMPHOID CELLS DIFFERENTIATED WITH RESPECT TO alpha-, gamma-, AND {micro}- HEAVY POLYPEPTIDE CHAINS AND TO ALLOTYPIC MARKERS AA1 AND AA2

doi:10.1084/jem.123.3.547

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RABBIT LYMPHOID CELLS DIFFERENTIATED WITH RESPECT TO $alpha$ -, $gamma$ -, AND µ- HEAVY POLYPEPTIDE CHAINS AND TO ALLOTYPIC MARKERS AA1 AND AA2

J. J. Cebra Ph.D.¹, J. E. Colberg M.D.¹, and S. Dray M.D.¹

¹ From the Department of Microbiology, University of Florida, Gainesville, and the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

Lymphoid cells present in spleen and lymph nodes of hyperimmunerabbits were found to be differentiated with respect to theclass of immunoglobulin heavy chain which they contained. Therelative proportions of cells containing the various heavy chainswere as follows: $alpha$ -chain (5 to 8%), µ-chain (14 to 21%),and $gamma$ -chain (71 to 81%). The allotypic markers Aa1 and Aa2, foundon heavy chains, were also found to be separately localizedin cells of Aa¹/Aa² heterozygous rabbits. The ratio of cellsin spleen and lymph nodes containing the Aa1 marker to thosecontaining the Aa2 marker varied with individual rabbits; therange was 53 to 88% Aa1 versus 12 to 47% Aa2.

Submitted on October 1, 1965

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