The Journal of Experimental Medicine, Vol 123, 487-503,
Copyright © 1966 by The Rockefeller University Press
SPECIFIC TRANSPLANTATION IMMUNITY IN RELATION TO ROUS SARCOMA VIRUS TUMORIGENESIS IN MICE
Nils Jonsson M.D.1 and
Hans Olof Sjögren M.D.1
1 From the Institute of Pathology, University of Lund, Lund, Sweden, and the Institute of Tumor Biology, Karolinska Institutet Medical School, Stockholm, Sweden
Tests for transplantation immunity and for the occurrence of virus-neutralizing serum antibodies were performed on mice, inoculated when newborn with the Schmidt-Ruppin strain of Rous sarcoma virus (RSV-SR). Mice developing no palpable primary sarcomas showed a clear-cut resistance against the isografting of established specifically antigenic Rous tumors. Transplantation tests performed on primary tumor hosts after extirpation of the tumors revealed neither any clear-cut immunity nor tolerance to the specific transplantation antigen(s). Serial pretreatment of operated primary tumor animals with irradiated autologous or syngeneic tumor cells resulted in a clear-cut transplantation immunity. Virus-neutralizing activity was only found in a few sera from newborn infected mice, and in these cases there was no positive correlation with the transplantation immunity.
It seems probable that a successful immunization against the RSV-SR specific transplantation antigen(s) prevents the development of primary tumors. There is no indication of any tolerance to this antigen in connection with the induction of primary tumors.
Submitted on October 31, 1965
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
