ELEVATED -GLOBULIN AND INCREASED ANTIBODY PRODUCTION IN MICE INFECTED WITH LACTIC DEHYDROGENASE VIRUS

¹ From the Laboratory of Microbiology, National Institute of Dental Research, and Metabolism Service, National Cancer Institute, Bethesda, Maryland

Infection of mice with the lactic dehydrogenase virus (LDV) resulted in an elevated level of -globulin. Histologic examination of the spleen and lymph nodes revealed that the number of germinal centers was greatly increased. Immunization with human -globulin showed that the capacity of the virus-infected animal to produce anti-human -globulin was greatly enhanced and that the virus acted as an adjuvant. From these experiments it is concluded that a virus infection (LDV) can affect the immunologic response of the host to a heterologous antigen.

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