The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 123, 341-346, Copyright © 1966 by The Rockefeller University Press

ARTICLE

THE STATE OF HEMOGLOBIN IN SICKLED ERYTHROCYTES

Chandler A. Stetson Jr. M.D.1

1 From the Department of Pathology, New York University School of Medicine, New York

Electron microscopic and other evidence have provided support for the hypothesis that the sickling phenomenon is due to the intracellular formation of long slender crystals of reduced sickle hemoglobin. The rapid growth of these crystals causing tenting of the cell membrane is responsible for the bizarre distortion of the erythrocytes and presumably for the disease itself.

Submitted on September 10, 1965


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