The Journal of Experimental Medicine
Randox clinical diagnostic solutions
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The Journal of Experimental Medicine, Vol 122, 1151-1160, Copyright © 1965 by The Rockefeller University Press

ARTICLE

STUDIES OF A MYXOVIRUS RECOVERED FROM PATIENTS WITH INFECTIOUS HEPATITIS : II. FINE STRUCTURE AND ELECTRON MICROSCOPIC DEMONSTRATION OF INTRACYTOPLASMIC INTERNAL COMPONENT AND VIRAL FILAMENT FORMATION



Philip H. Prose M.D.1, Samuel D. Balk 1, Harvey Liebhaber M.D.1, and Saul Krugman M.D.1

1 From the Departments of Pathology and Pediatrics, New York University School of Medicine, New York

WB virus has been shown to have a fine structure which is characteristic of members of the mumps-NDV-parainfluenza group of viruses.

Viral internal component has been demonstrated within the cytoplasm of infected cells. The incorporation of internal component into virus filaments at the cell surface has also been demonstrated. The evidence presented suggests that virus filament formation occurs by a process of invagination of the cell membrane about the coiled strands of internal component lying beneath the membrane.

 Submitted on June 28, 1965


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