The Journal of Experimental Medicine
Keystone Symposia
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The Journal of Experimental Medicine, Vol 122, 733-744, Copyright © 1965 by The Rockefeller University Press

ARTICLE

THE BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY : II. EFFECTS OF SENSITIZATION WITH STAPHYLOCOCCI AND OTHER MICROORGANISMS



Felix T. Rapaport M.D.1 and Randolph M. Chase Jr. M.D.1

1 From the Departments of Surgery and Medicine, and Institute of Reconstruction Plastic Surgery, New York University Medical Center, New York, and The Rockefeller University

Heat-killed strains of Staphylococcus aureus and Staphylococcus albus can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues or Group A streptococci. Challenge of suitably prepared recipients with first-set skin homografts obtained from unrelated randomly selected donors elicits white graft reactions or accelerated rejection of such grafts.

Other bacteria tested included Lancefield streptococcal groups B, C, D, E, G, H, L, and O, pneumococcus Types II, III, XIV and a rough strain, Corynebacterium xerosis, Bacillus subtilis, Escherichia coli, Aerobacter aerogenes, Salmonella typhimurium, Proteus vulgaris, Neisseria catarrhalis, Haemophilus influenzae, and two human virulent strains of Mycobacterium tuberculosis. None of these microorganisms was active in the induction of homograft sensitivity in the guinea pig. Pretreatment of recipients with Gram-negative bacterial suspensions was associated with a slight increase in the mean survival time of first-set skin homografts.

Results of this study suggest the presence in staphylococci, as well as in Group A streptococci, of antigens related in their biologic effects to tissue transplantation antigens.

 Submitted on May 17, 1965


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