The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 122, 665-671, Copyright © 1965 by The Rockefeller University Press

ARTICLE

ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XV. STUDIES ON THE IMMUNOGENICITY OF SYNTHETIC POLYPEPTIDES IN MICE



Paul Pinchuck Ph.D.1 and Paul H. Maurer Ph.D.1

1 From the Microbiology Department, New Jersey College of Medicine and Dentistry, Jersey City

The response of mice to synthetic linear polypeptides of known composition but random sequence has been studied. Neither Swiss mice nor a number of inbred strains could respond to copolymers of only 2 amino acids (G60L40, G60A40, G90T10). Upon introduction of as little as 4 mole per cent of a third amino acid, good immune responses were obtained, regardless of the nature of the third amino acid. The level of the immune response to a series of glu-lys-ala polymers increased with increasing alanine content of the polymer.

Submitted on May 20, 1965


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