The Journal of Experimental Medicine
Keystone Symposia
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The Journal of Experimental Medicine, Vol 122, 263-275, Copyright © 1965 by The Rockefeller Institute

ARTICLE

EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY

Yves Borel M.D.1, Marthe Fauconnet 1, and Peter A. Miescher M.D.1

1 From the New York University School of Medicine, Bellevue Medical Center, Department of Medicine, New York

In the primary response of mice and rabbits immunized with foreign red cells, 6-MP administration prolonged the formation of 19S antibody. 7S antibody formation was delayed and reduced in these animals.

Animals treated with 6-MP during primary response exhibited a preferential 19S response when challenged in the anamnestic response.

Animals immunized with small doses of antigen and treated with 6-MP only during the secondary response, reversed the usual antibody pattern and responded with preferential 19S antibody formation.

 Submitted on April 8, 1965


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