The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 121, 807-818, Copyright © 1965 by The Rockefeller Institute

ARTICLE

PATHOGENESIS OF INFLAMMATION : II. IN VIVO OBSERVATIONS OF THE INFLAMMATORY EFFECTS OF ACTIVATED HAGEMAN FACTOR AND BRADYKININ



Richard C. Graham Jr. M.D.1, Robert H. Ebert M.D.1, Oscar D. Ratnoff M.D.1, and John M. Moses M.D.1

1 From the Department of Medicine, Western Reserve University, Cleveland

Activated Hageman factor, when injected into the rabbit ear chamber, produces a delayed and prolonged inflammatory response characterized by prominent sticking and emigration of leucocytes. In contrast, preformed bradykinin evokes an immediate and more transient response in which leucocytic emigration occurs less frequently. It is concluded that either Hageman factor produces its inflammatory effects by mechanisms other than kinin release, or bradykinin released endogenously has effects quite different from those resulting from a single injection of the exogenous material.

Submitted on November 18, 1964


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