The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 121, 339-349, Copyright © 1965 by The Rockefeller Institute

ARTICLE

ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XIII. IMMUNOLOGICAL STUDIES WITH SYNTHETIC POLYMERS CONTAINING ONLY D- OR D- AND L-alpha-AMINO ACIDS



Paul H. Maurer Ph.D.1

1 From the Microbiology Department, New Jersey College of Medicine and Dentistry, Jersey City, New Jersey

It has been demonstrated that polymers consisting solely of D-alpha-amino acids are not immunogenic in rabbits, guinea pigs, man, and mouse, whereas the same polymers of L-alpha-amino acids are very effective antigens. This has been attributed to the importance of metabolizability of a polymer in contributing to its immunogenicity. In the glu-lys-ala series of polymers, the immunogenicity of a polymer of 2 L-amino acids and a D-amino acid appears to be governed by the immunogenicity of the 2 L-amino acids. However, some of the specificity may be directed towards configurations containing the D-amino acid. It has been noted that injections of rabbits with polymers of D-amino acids has resulted in a reduced response against the isomeric L polymer.

Submitted on November 8, 1964


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