The Journal of Experimental Medicine, Vol 121, 125-132,
Copyright © 1965 by The Rockefeller Institute
ONSET AND DURATION OF DNA SYNTHESIS IN ANTIBODY-FORMING CELLS AFTER ANTIGEN
Edward P. Cohen M.D.1 and
David W. Talmage M.D.1
1 From the Department of Microbiology, University of Colorado, School of Medicine, Denver
Within 5 hours after the intravenous injection of particulate antigen into the primarily immunized mouse, precursors of antibody-forming cells began DNA synthesis as shown by the incorporation of tritium-labeled thymidine. DNA synthesis continued for at least 24 hours and essentially stopped by 48 hours. No DNA synthesis in antibody-forming precursor cells occurred before the injection of antigen.
Submitted on September 17, 1964