The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 120, 1169-1188, Copyright © 1964 by The Rockefeller Institute

ARTICLE

ON THE RELATIONSHIPS BETWEEN THE gamma-GLOBULIN GENES OF THE GM SYSTEM : A STUDY OF GM GENE PRODUCTS IN SERA, MYELOMA GLOBULINS, AND SPECIFIC ANTIBODIES WITH SPECIAL REFERENCE TO THE GENE GMf



Lars Mårtensson 1

1 From the Institute of Bacteriology, University of Lund, Lund, Sweden

Gm types of sera from Caucasians and Negroes, of myeloma globulins, and of specific antibodies were investigated. In particular the relationship between the recently identified gene Gmf and other Gm genes was analyzed.

1. Caucasians were, with rare exceptions, either Gm(b+f+) or Gm(b-f-).

2. In Negroes, on the other band, type Gm(b+f-) was found to be common.

3. No myeloma globulins appeared to contain the product of more than 1 of the 3 genes Gma, Gmb, and Gmf, even though the large majority of normal individuals, as well as myeloma patients, possess 2 or all 3 of these genes.

4. The types Gm(a+b-f-) and Gm(a-b-f+) represented the 2 major groups among the gamma2-myeloma globulins; each comprised roughly 40 per cent. The types Gm(a- b+f-) and Gm(a-b-f-) are minor groups.

5. All Gm(x+) myeloma globulins were also Gm(a+). Approximately half of the Gm(a+) myeloma globulins were Gm(x+).

6. In the majority, but not in all, of Gm(a+) sera the anti-Rh antibodies were clearly Gm(a+). Similarly, the anti-Rh antibodies of Gm(f+) sera were most often, but not always, also Gm(f+). In contrast, only a minor proportion of Gm(b+) anti-Rh sera sensitized red cells to anti-Gm(b).

 Submitted on July 17, 1964


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