The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 120, 1041-1049, Copyright © 1964 by The Rockefeller Institute

ARTICLE

STUDIES ON ANTIBODY PRODUCTION : XI. VARIATION IN THE SECONDARY RESPONSE AS A FUNCTION OF THE LENGTH OF THE INTERVAL BETWEEN TWO ANTIGENIC STIMULI



Alfonz I. Fecsik M.D.1, William T. Butler M.D.1, and Albert H. Coons M.D.1

1 From the Department of Bacteriology and Immunology, Harvard Medical School, Boston

As the interval between two antigenic stimuli to mice is lengthened, the magnitude of the response to the second dose increases up to approximately 40 days; thereafter it remains at a fairly constant, high level.

Submitted on July 27, 1964


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