The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 120, 639-654, Copyright © 1964 by The Rockefeller Institute

ARTICLE

SEROLOGIC STRAIN DIFFERENTIATION IN TRACHOMA

Roger L. Nichols M.D.1 and Dorothy E. McComb 1

1 From the Department of Microbiology, Harvard University School of Public Health, Boston, and the Aramco Trachoma Research Program, Medical Department, Arabian American Oil Company, Dhahran, Saudi Arabia

An in vitro test for the differentiation of trachoma strain isolates was described. The method was based on absorption of trachoma antiserum followed by immunofluorescent staining of individual trachoma strains.

Nineteen trachoma strains were studied; two main types were identified. Evidence for quantitative and qualitative antigenic variation between the two types was presented. The limitations in practice and in theory of the test were emphasized.

 Submitted on June 2, 1964


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