H CHAIN SUBGROUPS OF MYELOMA PROTEINS AND NORMAL 7S gamma-GLOBULIN

doi:10.1084/jem.120.2.253

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ARTICLE

H CHAIN SUBGROUPS OF MYELOMA PROTEINS AND NORMAL 7S $gamma$ -GLOBULIN

Howard M. Grey M.D.¹ and Henry G. Kunkel M.D.¹

¹ From The Rockefeller Institute

Through the use of a variety of antisera to isolated myelomaproteins, four subgroups of 7S $gamma$ -globulin type proteins werereadily distinguished. The first, the Vi subgroup, consistedof ten of 64 myeloma proteins studied. The second, the We group,contained the majority of myeloma proteins. The third, the Gesubgroup, included three of 50 myeloma proteins. The fourthremains ill-defined and appears heterogeneous.

Counterpartsfor both the Vi and the Ge subgroup, were found in the Fr II $gamma$ -globulin and in the normal $gamma$ -globulin of all of a large numberof individual sera studied.

The unique antigenic character ofboth groups was localized to the H chains, although differentdeterminants were involved for different antisera. An essentialrole of intact disulfide bonds was apparent with certain rabbitantisera.

In addition to the special antigenic characteristics,the Ge subgroup showed in each instance a fast mobility forthe F fragments produced by papain which was not found for othermyeloma proteins.

Submitted on April 23, 1964

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