The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 120, 243-251, Copyright © 1964 by The Rockefeller Institute

ARTICLE

THE IMMUNOGLOBULINS OF MICE : II. TWO SUBCLASSES OF MOUSE 7S gamma2-GLOBULINS: gamma2a- AND gamma2b-GLOBULINS



John L. Fahey M.D.1, John Wunderlich M.D.1, and Robert Mishell M.D.1

1 From the Department of Health, Education, and Welfare, Public Health Service, The Metabolism Service and Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda

Two subclasses of mouse 7S gamma2-globulins are identified, and are designated gamma2a- and gamma2b-globulins. They are distinguished from 7S gamma1-globulins, gamma1A (ß2A)-globulins, and gamma1M-globulins of mouse serum. Antibody activity was detected among the gamma2a-globulins and gamma2b-globulins of hyperimmune mouse serum.

gamma2a- and gamma2b-myeloma proteins were identified. The genetically determined isoantigen, Iga-1, was present on gamma2a-myeloma proteins, but not on gamma2b-myeloma proteins.

These findings indicate a complexity among the 7S gamma2-globulins which must be taken into account in structural, functional, and genetic studies of immunoglobulins.

 Submitted on April 13, 1964


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