IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS: II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI

doi:10.1084/jem.119.4.643

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IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS : II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI

Melvin H. Kaplan M.D.¹ and Mary Louise Suchy ¹

¹ From the Department of Medicine, Metropolitan General Hospital, and Western Reserve University School of Medicine, Cleveland

Further evidence of a cross-reactive relationship between acell wall antigen of certain Group A streptococcal strains andmammalian heart tissue is provided by the demonstration thatgoat antisera to washed human or rabbit heart tissue homogenatesexhibit precipitation with cell wall extract preparations. Asingle line of precipitation was observed in agar gel diffusiontests. Precipitating activity of goat antiheart sera was relatedto the $gamma$ -globulin fraction in zone electrophoresis. The cellwall antigen was demonstrated in cell wall extracts of a Type5 and Type 19 but not of a Type 12 strain. Antigenic activitywas concentrated in the same neutral salt and chromatographicfractions of acid extracts of cell wall previously reportedto exhibit this activity by immunofluorescent inhibition ofthe cross-reaction of antistreptococcal serum with heart tissue.

Submitted on December 10, 1963

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