The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 119, 615-631, Copyright © 1964, by The Rockefeller Institute

ARTICLE

GAMMA GLOBULIN METABOLISM IN RABBITS DURING THE ANAMNESTIC RESPONSE

Evangelos A. Catsoulis M.D.1, Edward C. Franklin M.D.1, Murray Oratz Ph.D.1, and Marcus A. Rothschild M.D.1

1 From the Radioisotope Service, Veterans Administration Hospital, the Department of Medicine and Rheumatic Disease Study Group, New York University School of Medicine, and the Department of Biochemistry, New York University College of Dentistry, New York

1. Gamma globulin metabolism and distribution were studied employing rabbit gamma globulin (RGG)I131 24 times in 13 control rabbits. Similar studies were performed before and during the ananmestic response in 4 rabbits previously sensitized with a polyvalent pneumococcal vaccine.

2. During the ananmestic response, gamma-globulin levels increased from 1.0 to 6.0 gm/100 ml, and the gamma-globulin pool increased from 0.7 to 4.7 gm/kg. There was no change in the intravascular-extravascular partition of gamma globulin.

3. Gamma globulin degradation increased from 0.06 to 0.33 gm/kg/day during the 28 days of the immunization period while gamma globulin synthesis increased even further to average 0.47 gm/kg/day. Following the attainment of elevated gamma globulin levels the fractional rate of RGG-I131 turnover increased from 8.0 to 12.5 per cent/day.

4. No differences were noted in the metabolism of homologous or autologous gamma globulin regardless of the allotypic specificities.

 Submitted on November 19, 1963


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