The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 119, 83-104, Copyright © 1964, by The Rockefeller Institute

ARTICLE

EFFECTS OF ACIDIC AZOPROTEINS ON PLASMA TRIGLYCERIDE LEVELS AND ON THE HEPARIN-ACTIVATED CLEARING SYSTEM

J. D. Broome M.B.1

1 From the Department of Pathology, New York Hospital-Cornell Medical Center, New York

When injected into the rabbit 3 acidic azoproteins produced marked changes in the blood triglyceride levels. 4-Arsonophenylazoproteins, which were found to act similarly in 2 other mammalian species, produced a gross and prolonged hyperlipemia. 4-sulfono- and 4-carboxyphenylazoproteins in the rabbit produced an initial elevation and later lowering in blood triglyceride levels. The correlation between these changes and the action of the azoproteins on clearing factor lipase provides further evidence for the importance of this enzyme in fat transport mechanisms. 4-Arsonophenylazoprotein is powerfully inhibitory to the lipase. 4-Carboxy- and 4-sulfonophenylazoprotein in vivo initially inhibit the enzyme and later produce a heparin-like activation.

Submitted on September 4, 1963


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