The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 118, 619-626, Copyright © 1963, by The Rockefeller Institute

ARTICLE

ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE gamma1-MACROGLOBULINS

J. Gabriel Michael Ph.D.1 and Fred S. Rosen M.D.1

1 From the House of the Good Samaritan and the Department of Medicine, Children's Hospital Medical Center, and the Department of Pediatrics, Harvard Medical Center, Boston

"Natural" antibodies to representative species of Enterobacteriaceae were found to be principally associated with the gamma1-macroglobulin prepared from Cohn fraction III-I of pooled human plasma. The amount of antibodies present was estimated by measuring the bactericidal, hemagglutinating, mouse-protective, and opsonophagocytic activities of this fraction. Comparison with the antibody activity of gamma2-globulin of Cohn fraction II showed that up to 100 times more antibody activity on a weight basis was present in the macroglobulin fraction. These findings suggest that differences between natural and immune antibody result from the physicochemical properties of 2 different classes of immune globulin.

Submitted on June 3, 1963


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