The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 118, 41-53, Copyright © 1963, by The Rockefeller Institute

ARTICLE

COMPARISONS OF BENCE-JONES PROTEINS AND L POLYPEPTIDE CHAINS OF MYELOMA GLOBULINS AFTER HYDROLYSIS WITH TRYPSIN

J. H. Schwartz M.D.1 and G. M. Edelman M.D.1

1 From The Rockefeller Institute

L polypeptide chains of myeloma globulin and Bence-Jones protein isolated from the same patient were found to be identical after comparison of their tryptic hydrolysates by two-dimensional high voltage electrophoresis. The patterns of peptides from proteins belonging to antigenic group I differed markedly from those of proteins in antigenic group II. A partially purified H chain fraction was compared with L chains from the same myeloma protein. The tryptic hydrolysates yielded dissimilar patterns of peptides.

These data indicate that gamma-myeloma proteins contain two kinds of polypeptide chains, Hgamma chains and either LI or LII chains. The L chains appear to be identical with those comprising the Bence-Jones protein from the same patient.

 Submitted on March 20, 1963


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