The Journal of Experimental Medicine
Keystone Symposia
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The Journal of Experimental Medicine, Vol 117, 1063-1074, Copyright ©, 1963, by The Rockefeller Institute

ARTICLE

STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE



Thomas F. O'Brien M.D.1 and Albert H. Coons M.D.1

1 From the Department of Bacteriology and Immunology, Harvard Medical School, Boston

Incorporation of 5-bromodeoxyuridine (BUDR) in the culture medium for the 2nd, 3rd, or 4th day after in vitro antigen stimulation of rabbit popliteal lymph node fragments suppressed the in vitro anamnestic antibody response described previously. Before or after this 3-day period, BUDR had no measurable effect. The results suggest that the antibody response in this in vitro system depends upon cell multiplication during this period.

Submitted on March 3, 1963


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