The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 116, 477-490, ©Copyright, 1962, by The Rockefeller Institute

ARTICLE

REDUCTION OF SERUM COMPLEMENT IN RABBITS AFTER INJECTION OF ENDOTOXIN

Verne E. Gilbert M.D.1 and Abraham I. Braude M.D.1

1 From the Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh

Injection into rabbits of a consistently lethal dose of endotoxin regularly produced a rapid and sustained fall of complement levels and lowered the titers of antibody to endotoxin. Doses of endotoxin below the LD50 lowered complement levels sporadically but not the titers of antibody to endotoxin. The possibility is discussed that complement may be involved in the mechanisms responsible for the lethal action of endotoxin.

Submitted on June 6, 1962


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