The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 116, 347-364, Copyright, 1962, by The Rockefeller Institute

ARTICLE

THE ROLE OF ANTIBODY, DELAYED HYPERSENSITIVITY, AND INTERFERON PRODUCTION IN RECOVERY OF GUINEA PIGS FROM PRIMARY INFECTION WITH VACCINIA VIRUS

Robert M. Friedman M.D.1, Samuel Baron M.D.1, Charles E. Buckler 1, and Robert I. Steinmuller M.D.1

1 From the Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases and Division of Biologics Standard, Bethesda

In guinea pigs, methotrexate and x-radiation have been employed to block the development of delayed hypersensitivity and of antibody to vaccinia virus during experimental infection.

Animals whose specific responses were blocked by x-radiation and methotrexate recovered from vaccinia virus infection as rapidly as non-treated control animals suggesting that these responses were not essential in recovery of the infected animals.

A virus-inhibiting substance with the properties of interferon was present in skin of untreated and methotrexate- and x-radiation-treated animals infected with vaccinia virus.

 Submitted on May 3, 1962


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