The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 115, 1141-1148, Copyright, 1962, by The Rockefeller Institute

ARTICLE

THE SITE OF SYNTHESIS OF THE 19S gamma-GLOBULINS IN DYSGAMMAGLOBULINEMIA

Andre Cruchaud M.D.1, Fred S. Rosen M.D.1, John M. Craig M.D.1, Charles A. Janeway M.D.1, and David Gitlin M.D.1

1 From the Departments of Pediatrics and Pathology, Harvard Medical School, and from the Children's Hospital Medical Center and the Lying-In Hospital, Boston

Lymph nodes and splenic tissue from patients with congenital agammaglobulinemia and dysgammaglobulinemia and from normal subjects were studied with the use of immunofluorescence and histochemical stains to determine the site of synthesis of the 19S gamma1-globulins. The two patients with dysgammaglobulinemia had high serum concentrations of the 19S gamma1-globulins and a marked deficit of the 7S gamma-globulins. These patients, as well as agammaglobulinemic children, had only rare or no plasma cells in their tissues. Cells were identified in sections of spleen from a dysgammaglobulinemic child as well as from normal individuals which exhibited specific fluorescence with an anti-19S gamma-globulin antiserum adsorbed with 7S gamma2-globulins and which stained positively with PAS and methyl green pyronine. These cells resembled the transitional cells described by Fagraeus.

Submitted on February 22, 1962


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