The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 115, 1137-1140, Copyright, 1962, by The Rockefeller Institute

ARTICLE

STUDIES OF THE GENERALIZED SHWARTZMAN REACTION PRODUCED BY DIET : III. PARTIAL PREVENTION BY ANTIBIOTICS



Donald G. McKay M.D.1 and Ting-Chao Wong M.D.1

1 From the Department of Pathology, College of Physicians and Surgeons, Columbia University, New York City

A 4-fold reduction in the death rate of pregnant rats subjected to a diet capable of inducing the generalized Shwartzman reaction was obtained by the administration of oral absorbable and non-absorbable antibiotics. The possible mechanisms of this partial protection have been discussed.

Submitted on January 25, 1962


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