The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 115, 147-156, Copyright, 1962, by The Rockefeller Institute

ARTICLE

THE AMELIORATION OF HYPERVITAMINOSIS D IN RATS WITH VITAMIN A

Irwin Clark Ph.D.1 and C. Andrew L. Bassett M.D.1

1 From the Orthopaedic Research Laboratories, Departments of Orthopaedic Surgery and Biochemistry, Columbia University, College of Physicians and Surgeons, New York

The administration of relatively large amounts of vitamin A to hypervitaminotic D rats decreases the toxicity of this condition as evidenced by increased longevity, better weight gain, decreased soft tissue calcification and by considerable improvement in the histologic appearance of osseous structures.

Submitted on June 22, 1961


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