The Journal of Experimental Medicine
ThymUS '08
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The Journal of Experimental Medicine, Vol 114, 857-874, Copyright, 1961, by The Rockefeller Institute

ARTICLE

EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : I. PLATELET AGGREGATION AND RELEASE OF PLATELET FACTORS IN VITRO



Roger M. Des Prez M.D.1, Herbert I. Horowitz M.D.1, and Edward W. Hook M.D.1

1 From the Department of Medicine, The New York Hospital—Cornell Medical Center, New York

Incubation of platelet-rich rabbit plasma with E. coli endotoxin at 37°C results in platelet aggregation and transfer of platelet 5-hydroxytryptamine to plasma. Release of 5HT is influenced by dose of endotoxin, type of anticoagulant, and temperature of incubation. A heat-labile plasma factor is necessary for the platelet-endotoxin interaction. Additional studies have shown that incubation of endotoxin with platelet-rich rabbit plasma also results in release of platelet phospholipid and bactericidins active against B. subtilis.

Submitted on August 11, 1961


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