The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 114, 327-342, Copyright, 1961, by The Rockefeller Institute

ARTICLE

STUDIES ON INFECTION AND IMMUNITY IN EXPERIMENTAL TYPHOID FEVER : III. EFFECT OF PROPHYLACTIC IMMUNIZATION



Sidney Gaines Ph.D.1, Maurice Landy Ph.D.1, Geoffrey Edsall M.D.1, Adrian D. Mandel Ph.D.1, R.-J. Trapani Ph.D.1, and A. S. Benenson M.D.1

1 From the Walter Reed Army Institute of Research, Washington, D. C.

A study was made of the efficacy of various antityphoid immunizing agents in immunizing chimpanzees against typhoid fever produced by feeding viable S. typhosa.

It was found that both acetone-killed and heat-killed, phenol-preserved typhoid vaccines were effective in protecting against infection induced with either homologous or heterologous strains of typhoid bacilli.

Purified O antigen induced no discernible protection, but some immunity was afforded by the administration of purified Vi antigen.

 Submitted on May 31, 1961


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