The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Farquhar, J. W.
Right arrow Articles by Sokolow, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Farquhar, J. W.
Right arrow Articles by Sokolow, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 113, 587-597, Copyright, 1961, by The Rockefeller Institute

ARTICLE

PLASMA FIBRINOLYSIS IN MAN: THE EFFECT OF CHYLOMICRONS DERIVED FROM DIFFERENT DIETARY FATS

John W. Farquhar 1, Thomas C. Merigan 1, and Maurice Sokolow 1

1 From the Department of Medicine and the Cardiovascular Research Institute, University of California School of Medicine, San Francisco, and The Rockefeller Institute

The plasma fibrinolytic activity, measured in vitro, of 17 healthy normal young males was consistently and equally inhibited by prior ingestion of equal amounts of either a relatively saturated animal fat (butterfat) or a highly unsaturated vegetable fat (safflower oil).

This effect was further studied by the addition of purified chylomicrons derived from ingestion of either butterfat, safflower oil, or egg yolk to an in vitro system. The inhibitory effect was quantitatively similar in all experiments despite wide variations in composition of the fed fat and pronounced differences in fatty acid composition of the lipids of the chylomicrons.

It seems reasonable to suggest from our data that the proteins and the nonfatty acid portions of the chylomicron phospholipids may be important determinants of the inhibitory effect of chylomicrons on fibrinolysis.

 Submitted on November 20, 1960


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS