The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 112, 351-359, Copyright, 1960, by The Rockefeller Institute

ARTICLE

THE EFFECT OF DIPHTHERIA TOXIN ON THE METABOLISM OF HELA CELLS : II. EFFECT ON NUCLEIC ACID METABOLISM



Norman Strauss Ph.D.1

1 From the Department of Microbiology, Yale University, New Haven

The effect of toxin on the incorporation of uridine and thymidine into nucleic acids was investigated. P32 orthophosphate incorporation into the nucleoside phosphate fraction was also investigated. No early effect of toxin on nucleic acid synthesis was evident and only a slight effect of toxin on nucleoside phosphate formation was found prior to 1.5 hours after toxin addition. Both these processes, however, were found to be sensitive to dinitrophenol. These results are interpreted as indicating that toxin does not act by a general uncoupling of oxidation from phosphorylation. Other possible mechanisms of toxin action are proposed.

Submitted on April 20, 1960


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