The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 112, 249-255, Copyright, 1960, by The Rockefeller Institute

ARTICLE

BIOCHEMICAL STUDY OF CELLULAR ANTIGEN-ANTIBODY REACTION IN TISSUE CULTURE : II. RELEASE OF A PROTEASE INHIBITOR



Akira Tokuda M.D.1, Hideo Hayashi M.D.1, and Kinishiro Matsuba M.D.1

1 From the Department of Pathology, Mie Prefectural University School of Medicine, Tsu, Japan

Decrease in the protease activity of the culture fluid observed at later stages of the antigen-antibody reaction is believed to be due to the release of an inhibitor by the cells. The inhibitor was submitted to partial purification: it is heat-stable, non-precipitated by trichloracetic acid and non-dialyzable. It inhibits certain cellular and tissue proteases and papain but is inactive against trypsin. It is suggested that the balance between protease and anti-protease released may determine the intensity, extent, and duration of certain sensitization phenomena.

Submitted on December 8, 1959


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