The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 111, 761-772, ©Copyright 1960, by The Rockefeller Institute

ARTICLE

STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON : ACCELERATED CUTANEOUS REACTIVITY TO BACTERIAL ENDOTOXINS



Leung Lee M.D.1 and Chandler A. Stetson Jr. M.D.1

1 From the Department of Pathology, New York University College of Medicine, New York

Rabbits given single injections of endotoxin and then skin-tested with endotoxin from 1 day to 1 month later exhibit accelerated skin reactions resembling the Arthus phenomenon.

Injection of one endotoxin alters the subsequent reactivity of rabbits to other endotoxins as well.

The state of altered reactivity can be transferred with serum, and appears to be related to the presence of non-precipitating cross-reactive antibody, rather than to specific precipitating antibody.

 Submitted on January 24, 1960


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