The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 111, 339-349, ©Copyright 1960, by The Rockefeller Institute

ARTICLE

ON THE ROLE OF RIBONUCLEIC ACID IN ANIMAL VIRUS SYNTHESIS : I. STUDIES WITH 5,6-DICHLORO-1-ßbeta;-D-RIBOFURANOSYLBENZIMIDAZOLE



Igor Tamm M.D.1, Marjorie M. Nemes Ph.D.1, and Suydam Osterhout M.D.1

1 From The Rockefeller Institute

Adenosine, but not guanosine, was capable of blocking the inhibitory effect of 5,6-dichloro-1-ß-D-ribofuranosylbenzimidazole (DRB) on influenza virus multiplication in the chorioallantoic membrane in vitro. At virus inhibitory concentrations DRB caused marked inhibition in uptake of adenosine-8-C14 into RNA of uninfected host cells, but it had little effect on uptake of C14-L-alanine into host cell proteins or on cellular oxygen consumption. The activity of DRB in inhibiting multiplication of the DNA-containing adenovirus was similar to its inhibitory activity on multiplication of the RNA-containing influenza virus. These and earlier results are discussed from the point of view of the important role of RNA in the reproduction of DNA-containing viruses.

Submitted on November 24, 1959


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