The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 111, 195-200, ©Copyright 1960, by The Rockefeller Institute

ARTICLE

THE PATHOLOGIC EFFECTS OF INTRAVENOUSLY ADMINISTERED SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. ACUTE GLOMERULONEPHRITIS IN RATS



Baruj Benacerraf M.D.1, Jacobus L. Potter M.R.C.P.E.1, Robert T. McCluskey M.D.1, and Frederick Miller 1

1 From the Department of Pathology, New York University—Bellevue Medical Center, New York

The intravenous administration to rats of soluble antigen-antibody complexes in antigen excess resulted in acute glomerulonephritis. This occurred with both rabbit antiovalbumin and rabbit anti-BSA systems.

The rats so treated regularly showed proteinuria and elevation of blood urea nitrogen.

These findings are compared with those reported in rats injected with anti-kidney serum.

 Submitted on September 11, 1959


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