The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 111, 171-180, ©Copyright 1960, by The Rockefeller Institute

ARTICLE

SUPPRESSION OF EXPERIMENTAL "ALLERGIC" ENCEPHALOMYELITIS IN GUINEA PIGS BY ENCEPHALITOGENIC PROTEINS EXTRACTED FROM HOMOLOGOUS BRAIN

Cheng-Mei Shaw M.D.1, Willson J. Fahlberg Ph.D.1, Marian W. Kies Ph.D.1, and Ellsworth C. Alvord Jr. M.D.1

1 From the Departments of Neurology, Pathology, and Microbiology, Baylor University College of Medicine, Houston, and the Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland

The intradermal injection of aqueous solutions of certain homologous neural proteins will suppress the encephalomyelitis which is induced in guinea pigs by the previous injection of whole homologous brain with Freund's adjuvants. These neural proteins extracted by dilute acid from defatted guinea pig brain are themselves highly encephalitogenic when injected with adjuvants, but the specificity of this suppression for encephalitogenic as compared to non-encephalitogenic extracts remains to be proven.

Suppression is probably not due to a non-specific stress reaction, as indicated by the absence of suppression by intradermal injections of alcohol and by statistically insignificant and inconstant effects of similar injections of tuberculin.

 Submitted on August 5, 1959


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